If you’ve read some of our previous blogs, you’ll be aware that our most cited sources are from published medical literature, freely available online. When we write about CBD and its effects, we don’t infer that the same effects are guaranteed from our products. This is due to the way in which the trial data are published and the lack of dosage information. This in turn makes it impossible for any company to say that their products will have the same effect as those found in trial data.
Our position is supported by the literature and interestingly, the conclusions we found from a systematic review titled ‘What Do You Know About Maryjane? A Systematic Review of the Current Data on the THC:CBD Ratio’ neatly summarises the research landscape when considering benefits. It concludes:
‘While there is evidence that cannabis provides medical benefits, research is lacking on standardization of medical cannabis use in modern medical practices.’
Google search trends tell us that a substantial number of searches are from people who want to know how CBD might benefit them, popular search terms include:
- CBD oil benefits?
- CBD health benefits?
- What can CBD help with?
- CBD benefits for pain?
Using sources, we consider reliable, here are the main outcomes and results that might help to answer some of these questions. We’ll use papers from PubMed searches and will use direct quotes where possible, this is to ensure that the outcomes and findings are reflected as accurately as possible:
CBD for epilepsy
A trial for patients with treatment-resistant epilepsy found that cannabidiol might reduce seizure frequency and might have an adequate safety profile in children and young adults with highly treatment-resistant epilepsy.
CBD for health and anxiety
A study in New Zealand with 400 people tested outcomes associated with taking CBD and changes in physical pain or anxiety. Participants reported an increase of describing overall quality of health. Patients with non-cancer pain and mental-health symptoms achieved improvements to patient-reported pain and depression and anxiety symptoms. There were no major adverse effects. Positive side effects reported included improved sleep and appetite.
CBD for Pain relief
A study in Florida was conducted following passage of the state’s first medical marijuana law and captured the perceived benefits, side effects, and beliefs expressed by patients in palliative (pain relief) care. Patients reported improvements in pain, appetite, and nausea. None of the patients had used CBD prior to the onset of their chronic illness. 21% of THC users and 21% of CBD users thought that their substance was helping to cure their illness.
CBD for siezures
Thirty-five studies, including four RCTs, have assessed the benefits and harms of cannabis-based products in paediatric (childhood) epilepsy. A very recent systematic review looked at these studies and established fairly strong conclusions. Data from both randomized controlled trials and non-randomized studies suggest that cannabidiol reduces seizure frequency and increases treatment response; and supports findings that cannabidiol probably reduces the frequency of seizures among children with drug-resistant epilepsy.
In conclusion, so far
The data, outcomes and conclusions from many of these publications are varied. One of the most fascinating assessments found via PubMed is in article authored by Donald I. Abrams, Professor of Clinical Medicine at University of California San Francisco. In the summary available from professor Abrams publication, we thought the following assertions were most valuable and best to conclude on:
‘Cannabis is a useful botanical with a wide range of therapeutic potential. Global prohibition over the past century has impeded the ability to study the plant as medicine.’
‘The system of cannabinoid receptors and endogenous cannabinoids (endocannabinoids) has likely developed to help us modulate our response to noxious stimuli. Phytocannabinoids also complex with these receptors, and the analgesic effects of cannabis are perhaps the best supported by clinical evidence.’
‘Cannabis and its constituents have also been reported to be useful in assisting with sleep, mood, and anxiety. Despite significant in vitro and animal model evidence supporting the anti-cancer activity of individual cannabinoids-particularly THC and cannabidiol (CBD)-clinical evidence is absent.’
‘A single intervention that can assist with nausea, appetite, pain, mood, and sleep is certainly a valuable addition to the palliative care armamentarium.’
We agree! Let us know your thoughts, like, link, share and comment.